GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs6500602 | 1 | rs12447826 | chr16:4464617 | HMOX2 | chr16:4524719-4560347:+ | 0.46 | 4.72 | 1.68E-5 | Schizophrenia |
| UVM | cis | rs10935120 | 1 | rs12490835 | chr3:134223730 | ANAPC13 | chr3:134196547-134204865:- | 0.46 | 7.06 | 3.0E-9 | Height |
| UVM | cis | rs12681963 | 1 | rs12547941 | chr8:29980332 | MBOAT4 | chr8:29989188-30002200:- | 1.07 | 4.86 | 1.03E-5 | Migraine |
| UVM | cis | rs9902453 | 1 | rs12600855 | chr17:28279591 | EFCAB5 | chr17:28256874-28435469:+ | 0.4 | 5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9902453 | 1 | rs12600993 | chr17:28291222 | EFCAB5 | chr17:28256874-28435469:+ | 0.4 | 5.09 | 4.57E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs2346177 | 1 | rs12619985 | chr2:46641627 | ATP6V1E2 | chr2:46738988-46769696:- | -0.53 | -4.63 | 2.29E-5 | HDL cholesterol |
| UVM | cis | rs10935120 | 1 | rs12637751 | chr3:134266124 | ANAPC13 | chr3:134196547-134204865:- | -0.46 | -6.87 | 6.1E-9 | Height |
| UVM | cis | rs4395360 | 1 | rs12696052 | chr3:157322963 | C3orf55 | chr3:157261159-157319019:+ | -0.41 | -4.6 | 2.56E-5 | Body mass index |
| UVM | cis | rs1411478 | 1 | rs12744212 | chr1:180952516 | STX6 | chr1:180913175-180992046:- | -0.58 | -5.69 | 5.07E-7 | Progressive supranuclear palsy |
| UVM | cis | rs1411478 | 1 | rs12754041 | chr1:180957962 | STX6 | chr1:180913175-180992046:- | -0.58 | -5.69 | 5.07E-7 | Progressive supranuclear palsy |
| UVM | cis | rs7973719 | 1 | rs12828040 | chr12:7326541 | PEX5 | chr12:7341759-7371167:+ | 0.75 | 10.32 | 1.78E-14 | IgG glycosylation |
| UVM | cis | rs7973719 | 1 | rs12828421 | chr12:7335217 | PEX5 | chr12:7341759-7371167:+ | -0.74 | -10.3 | 1.94E-14 | IgG glycosylation |
| UVM | cis | rs12889813 | 1 | rs12889813 | chr14:24306537 | NGDN | chr14:23938898-23947401:+ | 0.65 | 5.16 | 3.52E-6 | Antibody level in response to infection |
| UVM | cis | rs2028299 | 1 | rs12910992 | chr15:90372465 | AP3S2 | chr15:90373832-90456222:- | -0.69 | -5.9 | 2.3E-7 | Type 2 diabetes |
| UVM | cis | rs12971120 | 1 | rs12971120 | chr18:72174023 | CNDP2 | chr18:72163597-72188356:+ | 0.72 | 5.41 | 1.41E-6 | Refractive error |